A Computational Approach to Soft-Tissue Fluid-Structure Interaction

Motivation Cerebral disorders affect millions of people around the world. Despite progress in science and medicine, accurate diagnosis and treatment of brain related diseases is hampered due to the lack of proper understanding of the pathophysiology of such disorders. The fluid-soft tissue interaction problem is fundamental in addressing open challenges crucial for the understanding of intracranial dynamics. The challenge includes quantifying mechanical interactions of the expanding cerebral vasculature and the soft tissues of the brain. In this study, we present the mathematical framework to solve the governing system of equations of the fluid-structure interaction (FSI) problem using numerical techniques [1]. Methodology The fluid and solid transport equations of mass and momentum are transformed into a moving, body-fitted coordinate system using generalized curvilinear coordinates [2]. We extend the mapping relationships by computing the motion of conformal reference coordinate system relative to a fixed observer. The model incorporates EulerianLagrangian method to consistently track sharp deformable interfaces between the fluid and solid. The equations describing fluid-structure interaction are coupled and consist of a nonlinear system of partial differential equations (PDEs). The governing PDEs are discretized using the finite volume method in both structured and unstructured meshes [3]. Simultaneous solution approach using inexact Newton method for the non-linear system and a Krylov subspace based method for the linear subsystem (GMRES method) was used instead of fixed-point iteration methods like SIMPLE algorithm [1].